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KMID : 0363319910120020074
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Journal of Korean Oriental Internal Medicine
1991 Volume.12 No. 2 p.74 ~ p.88
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Effects of GooSunSan(九仙散) Extract on the Contraction of Isolated guinea pig’s various kinds smooth muscles
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Lyu Dong-Soo
Han Sang-Hwan
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Abstract
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In order to study the effects of Goosunsan known clinically for their effects of treatment for cough and asthmas the study was carried out to investigate the effect of Goosunsan extract on the contractile force of the isolated guinea pig’s vaviovs kinds smooth muscles and elucidate its mechanism
The result were obtained as follows:
1. The isolated trachea & ileum smooth muscles of guinea pig was suspended in the organ bath with oxygenated kreb’s Henselsite bicarbonate buffer solution at 37℃, and the developed tension by the drug was recorded with Isometric transducer (nacro F-60). The resting tension was approximately 0.5g.
2. The isolated trachea & ileum smooth muscles of guinea pig was remakably relaxed by the administration of Goosunsan.
3. The contractile response of the trachea smooth muscle of the isolated guinea pig to histamine 10-4 M was remakably by Goosunsan extract.
4. The contractile response of the ileum smooth muscle of the isolated guinea pig to histamine 10-4 M was remakably by Goosunsan extract.
5. The contractile response of the trachea smooth muscle of the isolated guinea pig to acetylcholine 10-4 M was remakably by Goosunsan extract.
6. The contractile response of the ileum smooth muscle of the isolated guinea pig to acetylcholine 10-4 M was remakably by Goosunsan.
7. The contractile response of the trachea smooth muscle of the isolated guinea pig to 5-hydroxytryptamine 10-4 M was remakably by Goosunsan.
8. The contractile response of the ileum smooth muscle of the isolated guinea pig to 5-hydroxytryptamine 10-4 M was remakably by Goosunsan.
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